According to Afar, Melvald’s General Store, where Joyce Byers works in Stranger Things, is at 4 Second Street in Jackson, Georgia. GPB noted that the building looked to be under construction with no exterior signage when its reporter visited, so do not expect a storefront.
The former Radio Shack from the show sits next to the general store. Explore Georgia’s listing for Jackson Escape Games says an escape-room business now operates inside it, with four of its five games themed after the show.
Treat this as a street-view stop on the way around the square. Our Stranger Things filming locations guide covers the rest of downtown Jackson.